2021-05-19 11:20 Methylation, the introduction of a methyl group into a molecule or compound, can have stereoelectronic effects on micromolecules and biomacromolecules, which cause various biological effects, including increased potency, protection against enzyme metabolism, and so forth. The insertion of one or more methyl groups into a bioactive molecule can change the solubility, bioavailability, lipophilicity, interaction with target proteins, metabolism, and pharmacokinetic/pharmacodynamics properties. Hence, the methyl group can change the pharmacological properties of a molecule. Due to the important role of methylation strategy in drug design, methylation analysis service is an essential technique at every stage of drug discovery.
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