2020-08-17 19:12 A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) modeling as a rational drug design tool has rece ... дальше
2020-08-17 19:12 MD simulation is particularly useful in computer-aided drug discovery (CADD) for the identification of hidden or allosteric binding sites, enhancement of traditional virtual screening methods, and direct prediction of the binding energy of small mole ... дальше
2020-08-17 19:11 The outbreak of novel coronavirus, the first coronavirus to cause a global pandemic, has forced an acceleration in the development of antiviral drugs against the virus. Creative Biostructure is a professional contract research organization in the fie ... дальше
2020-08-17 19:11 The rapid development of instrument and data processing technology, especially the invention of electron microscopy, has brought great help to obtain the ultrastructure of viral particles. Equipped with state-of-the-art optical microscopy, electron m ... дальше
2020-08-17 19:11 Creative Biostructure uses homology modeling to help you predict the 3D structure of related target proteins in coronavirus research. We have extensive experience in generating structure models of various types of proteins and protein complexes. The ... дальше
2020-08-17 19:11 Determining the three-dimensional (3D) structure of proteins is critical for understanding the mechanism of coronavirus infection, discovering potential drug targets and structure-based drug design. Rapid advances in methodologies for protein express ... дальше
2020-07-13 11:34 Scanning electron microscopy (SEM) is characterized by simple sample preparation, wide adjustable magnification range, high image resolution, and large depth of field. SEM technology can scan the surface morphology of the sample by emitting a bright ... дальше
2020-07-13 11:33 The ultra-thin section electron microscopy (EM) technology is an effective means to observe the characteristics of viruses and the interaction between viruses and host cells. Creative Biostructure provides ultra-thin section EM services combined with ... дальше
2020-07-13 11:33 High-resolution microscopy is essential for visualizing viral particles, and the acquisition of morphological characteristics of viral particles depends on the resolution. Transmission electron microscopy (TEM) is the starting point for obtaining the ... дальше
2020-07-13 11:30 Cryo-electron tomography (cryo-ET) is an approach for resolving polymorphic structures such as cells and organelles in a near-natural state and can provide a three-dimensional (3D) snapshot of viral particles in the host cell environment. The cryo-el ... дальше