2021-04-22 21:14
Interactions between biological macromolecules regulate various biological processes. Many molecular biology and biochemistry methods have been developed to detect this interaction, such as pull-down assay, co-immunoprecipitation (Co-IP), yeast two-h
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2021-04-22 21:14
Isothermal titration calorimetry (ITC) is widely used to detect the affinity and enthalpy of interactions between proteins and/or other molecules. In addition, the quantitative nature of ITC is useful in the characterization of recombinant proteins,
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2021-04-22 21:13
Creative Biostructure provides comprehensive services for the study on the interaction of biological macromolecules such as proteins involved in coronavirus research. Similar to surface plasmon resonance (SPR), bio-layer interferometry (BLI) is also
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2021-04-22 21:13
Creative Biostructure is a leading service supplier in the field of structural biology with a team of specialists specializing in contract research services for basic and preclinical research related to coronavirus infection. Currently, we have estab
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2021-04-22 21:13
The three-dimensional (3D) reconstruction technology of single-particle cryo-electron microscopy (cryo-EM) involves a complex image processing process from two-dimensional (2D) projection images to a 3D reconstruction model. Creative Biostructure cur
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2021-04-22 21:12
The latest technological advances in sample preparation, algorithm, and detector have made single-particle cryo-electron microscopy (cryo-EM) analysis a popular approach for solving macromolecular structures at near-atomic-resolution. After obtaining
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2021-04-22 21:12
The quality of X-ray diffraction data of the protein crystal can determine the success rate of the subsequent steps of structure determination and the reliability of the reconstructed three-dimensional (3D) structural model. After successfully obtain
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2021-04-22 21:12
The necessary condition for successful X-ray crystallographic analysis is to obtain a single crystal of the target protein that meets the X-ray diffraction standard. The data are then collected by X-ray diffraction from a single crystal with an order
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2021-04-02 06:32
Protein structure is significant to its function, so protein structure prediction is an important part of bioinformatics analysis for protein. To perform biological functions normally, protein molecules fold into one or more spatial conformations dri
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